Pnm-29: Effects of Vitamin D Supplementation in Reproductive Function of Women with Polycystic Ovary Syndrome

Background Vitamin D deficiency is common in women with PCOS. Vitamin D is thought to influence the development of PCOS through gene transcription, and hormonal modulation influences insulin metabolism and fertility regulation. Therefore, the aim of this review article is to study the effects of vitamin D supplementation in reproductive function of PCOS women. MaterialsAndMethods This review article prepared by studying of articles obtained from Google and PubMed sites with key words such as polycystic ovary syndrome; vitamin D; reproductive function. Results An intervention study investigated whether vitamin D and calcium dysregulation contribute to the development of follicular arrest, resulting in reproductive and menstrual dysfunction. Thirteen vitamin D-deficient women with PCOS were supplemented with vitamin D combined with calcium which increased 25OHD levels. This resulted in normalized menstrual cycles within 2 months for seven of the nine women with menstrual dysfunction, two women became pregnant and the other four maintained their normal menstrual cycles. In a randomized clinical trial investigating the effects of calcium– vitamin D and metformin in regulating the menstrual cycle, 60 infertile women with PCOS were randomized to one of the three treatments consisting of 1000 mg calcium + 400 IU vitamin D per day; 1000 mg calcium + 400 IU vitamin D + 1500 mg/day metformin, or 1500 mg/day metformin. The number of dominant follicles (14 mm) during the 2-3 months of follow-up was higher in the calcium–vitamin D-metformin group than in either of the other two groups. In a case control study, 100 infertile PCOS women were randomly divided into two groups. Group I (n=50) were treated with metformin, and group II (n=50) treated with metformin plus Calcium and Vitamin D for 6 months. A better improvement was gained in regulating menstrual abnormalities, follicle maturation and infertility in group II compared with group I. Conclusion The results of this review article indicated a beneficial effect of vitamin D supplementation on menstrual dysfunction.